P. falciparum malaria recrudescence in a cancer patientEmanuele Focà, Roberto Zulli, Fabio Buelli, Massimiliano De Vecchi, Antonio Regazzoli, Francesco CastelliInstitute for Infectious and Tropical Diseases, University of Brescia; Department of Internal Medicine, Spedali Civili General Hospital, Brescia; Biochemistry Laboratory, Spedali Civili General Hospital, Brescia, ItalyPage 33-34 - Vol. 17 N. 1 - 2009 Persons living for long periods of time in malaria hyper-endemic areas may suffer from hyper-reactive malarial splenomegaly (HMS), a frequent cause of splenomegaly in such areas. Splenomegaly and sub-microscopic P. falciparum parasitaemia are hallmarks of HMS. Spleen has been suggested to play a protective antimalarial role and splenectomy may trigger symptomatic malaria attacks. Other causes of immune suppression may possibly reactivate latent malaria parasites. We report the case of an Italian 60-year-old male, who had spent 33 years in sub-Saharan Africa, who experienced a P. falciparum malaria attack 12 months after his return to Italy, concomitantly with a diagnosis of lung carcinoma possibly impairing his immune system.
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